menaquinone-7 (MK-7) → has no observed adverse effect level (NOAEL) → 10 mg/kg body weight/day
“The no observed adverse effect level (NOAEL) of MK-7, when administered orally to rats for 90 days, was considered to be equal to 10 mg/kg body weight/day”
menaquinone-7 (MK-7) → has median lethal dose (LD50) → greater than 2000 mg/kg body weight
“the median lethal dose (LD(50)) of MK-7 after a single oral administration in mice was determined to be greater than the limit dose level of 2000 mg/kg body weight”
Lactobacillus salivarius CECT5713 → has no adverse effects → mouse body weight or food intake
dose: 5 x 10^8, 2 x 10^9, or 10^10 cfu/mouse per dayduration: 28 daysadministration: oral
“Oral administration of L. salivarius CECT5713 to mice had no adverse effects on mouse body weight or food intake.”
MFGM-enriched formulas → met → primary safety endpoint of non-inferiority in weight gain
“Both MFGM-enriched formulas met the primary safety endpoint of non-inferiority in weight gain and were generally well tolerated, although a higher rate of eczema was observed in the MFGM-P group”
oldest early splits → had → less fruit fresh weight
“At harvest the oldest early splits had less fruit fresh weight, lower kernel moisture, smaller shells, and more shell discoloration compared with early splits formed in the period before harvest and with normal nuts.”
aspartame → has no persistent changes → vital signs, body weight, standard laboratory tests, fasting blood levels of aspartic acid, phenylalanine, other amino acids, methanol, blood formate levels, 24-hour urinary excretion of formate
dose: 75 mg/kg per dayduration: 24 weeks
“No persistent changes over time were noted in either group in vital signs; body weight; results of standard laboratory tests; fasting blood levels of aspartame's constituent amino acids (aspartic acid and phenylalanine), other amino acids, and methanol; or blood formate levels and 24-hour urinary excretion of formate.”
selenium → has maximum safe single oral dose → 0.05 mg Se/kg body weight
“The maximum safe single oral dose of selenite, selenate, DL-selenocysteine, or DL-selenomethionine is suggested as 0.05 mg Se/kg body weight (milligrams of selenium per kilogram of body weight).”
selenium → has maximum safe multiple oral dose → 5 μg Se/kg body weight
“The maximum safe multiple oral dose is suggested as 5 μg Se/kg body weight.”
raw, soaked, and germinated navy beans → caused → weight loss and death in rats
duration: 8-16 days
“Rats fed raw, soaked, and germinated navy beans as a source of dietary protein lost weight and died 8–16 days after the beginning of the experiment”
melamine → has a Tolerable Daily Intake (TDI) of → 0.2 mg/kg body weight
“From the available toxicological data, a Tolerable Daily Intake (TDI) of 0.2 mg/kg body weight was established for melamine.”