Lacticin 3147 displays activity in buffer against Gram‐positive bacterial pathogens which appear insensitive in standard plate assays
Mary Galvin, Colin Hill, R. Paul Ross
Letters in Applied Microbiology
Abstract
Lacticin 3147 is a broad-spectrum bacteriocin produced by Lactococcus lactis subsp. lactis DPC3147, which has been shown to be active against a range of food-borne bacteria. The reported inhibitory range for lacticin is extended to include methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis, penicillin-resistant Pneumococcus, Propionibacterium acne and Streptococcus mutans. This extended host range is not obvious from traditional agar plate-based methods, but reductions in bacterial cell numbers by up to 6 log10 cfu ml-1 was observed after 2 h in time-kill curve studies conducted in broth, suggesting that the bacteriocin may have potential as a therapeutic agent in the treatment of human infections.
Extracted Claims
6 claims extracted from this paper into the knowledge graph
Lacticin 3147 inhibits Streptococcus mutans
“The reported inhibitory range for lacticin is extended to include Streptococcus mutans”
Lacticin 3147 inhibits Propionibacterium acne
“The reported inhibitory range for lacticin is extended to include Propionibacterium acne”
Lacticin 3147 inhibits methicillin-resistant Staphylococcus aureus
“The reported inhibitory range for lacticin is extended to include methicillin-resistant Staphylococcus aureus”