2024peer-reviewed38 citations
Corticosteroids in Sepsis and Septic Shock: A Systematic Review, Pairwise, and Dose-Response Meta-Analysis
Tyler Pitre, Katherine Drover, Dipayan Chaudhuri, Dena Zeraaktkar, Kusum Menon, Hayley B. Gershengorn +6 more
Critical Care Explorations
Abstract
We found that corticosteroids may reduce mortality and increase shock reversal but they may also increase the risk of hyperglycemia, hypernatremia, and neuromuscular weakness. The dose-response analysis indicates optimal dosing is around 260 mg/d of hydrocortisone or equivalent.
Concepts
Septic shockMeta-analysisMedicinePairwise comparisonSepsis