<i>Bifidobacterium</i> and the intestinal mucus layer

Abstract

<i>Bifidobacterium</i> species are integral members of the human gut microbiota and these microbes have significant interactions with the intestinal mucus layer. This review delves into <i>Bifidobacterium</i>-mucus dynamics, shedding light on the multifaceted nature of this relationship. We cover conserved features of <i>Bifidobacterium</i>-mucus interactions, such as mucus adhesion and positive regulation of goblet cell and mucus production, as well as species and strain-specific attributes of mucus degradation. For each interface, we explore the molecular mechanisms underlying these interactions and their potential implications for human health. Notably, we emphasize the ability of <i>Bifidobacterium</i> species to positively influence the mucus layer, shedding light on its potential as a mucin-builder and a therapeutic agent for diseases associated with disrupted mucus barriers. By elucidating the complex interplay between <i>Bifidobacterium</i> and intestinal mucus, we aim to contribute to a deeper understanding of the gut microbiota-host interface and pave the way for novel therapeutic strategies.