The role of heavy metals in the development of colorectal cancer
Yongsheng Li, Jingwei Lou, Shaozhong Hong, Dengfeng Hou, Yandong Lv, Zhiqiang Guo +4 more
BMC Cancer
Abstract
The results showed that low level of Se and high levels of V, As, Sn, Ba, Pb, Cr, and Cu increased the risk of CRC. Sb and Tl may cause BRAF V600E mutations, leading to MSI. XRCC1 (rs25487) was positively correlated with Se but negatively correlated with Co. The expression of ERCC1 may be related to MSS, while the XRCC1 (rs25487) polymorphism is related to MSI.
Concepts
Internal medicineColorectal cancerMedicineGastroenterology