A Novel Streptococcus thermophilus FUA329 Isolated from Human Breast Milk Capable of Producing Urolithin A from Ellagic Acid
Qitong Liu, Shu Liu, Qinwen Ye, Xiaoyue Hou, Guang Yang, Jing Lu +3 more
Foods
Abstract
Urolithin A, a metabolite of ellagic acid, has many beneficial biological activities for people. Strains capable of producing urolithin A from ellagic acid have the hope of becoming the next-generation probiotics. However, only a few species of these strains have been reported. In this study, FUA329, a strain capable of converting ellagic acid to urolithin A in vitro, was isolated from the breast milk of healthy Chinese women. The results of morphological observation, physiological and biochemical tests, and 16S rRNA gene sequence analysis confirmed that the strain FUA329 was <i>Streptococcus thermophilus</i>. In addition, the <i>S. thermophilus</i> FUA329 growth phase is consistent with the degradation of ellagic acid, and urolithin A was produced in the stationary phase, with a maximum concentration of 7.38 μM at 50 h. The corresponding conversion efficiency of urolithin A from ellagic acid was 82%. In summary, <i>S. thermophilus</i> FUA329, a novel urolithin A-producing bacterium, would be useful for the industrial production of urolithin A and may be developed as a next-generation probiotic.
Extracted Claims
2 claims extracted from this paper into the knowledge graph
urolithin A has beneficial biological activities
“Urolithin A, a metabolite of ellagic acid, has many beneficial biological activities for people.”
ellagic acid is converted to urolithin A
“In this study, FUA329, a strain capable of converting ellagic acid to urolithin A in vitro, was isolated from the breast milk of healthy Chinese women. The results of morphological observation, physio...”