Bioaccessibility and antioxidant activity of β-carotene loaded nanostructured lipid carrier (NLC) from binary mixtures of palm stearin and palm olein
Miftakhur Rohmah, Anton Rahmadi, Sri Raharjo
Heliyon
Abstract
β-carotene (βC) is an essential nutrient for health. It is a potent antioxidant, anti-cancer, and anti-inflammatory substance. However, βC has high hydrophobicity property, indicating a low absorption level in the digestive tract. The bioavailability of βC is reasonably low. Lipid-based delivery systems such as nanostructured lipid carriers (NLC) potentially can help to overcome this problem. This research evaluated the bioaccessibility of the nanostructured mixture of palm stearin (PS) and palm olein (PO) and the antioxidant activity of βC in the structure. β-carotene bioaccessibility was studied by measuring the micellization during <i>in vitro</i> digestion. Antioxidants activity was measured by 2.2'-azino-bis (3-ethylbenzothiazoline- 6-sulphonic acid) (ABTS) and 2, 2 - diphenyl -1- picrylhydrazyl (DPPH) reduction methods. <i>In vitro</i> gastrointestinal digestion model indicated that nanostructured lipid carrier enhanced bioaccessibility and antioxidants activity of βC. This suggests that the formulated NLC system can be used effectively to deliver lipophilic bioactive such as βC in beverage products.
Extracted Claims
4 claims extracted from this paper into the knowledge graph
β-carotene has low absorption level in the digestive tract
“However, βC has high hydrophobicity property, indicating a low absorption level in the digestive tract.”
β-carotene has high hydrophobicity
“β-carotene (βC) is an essential nutrient for health. It is a potent antioxidant, anti-cancer, and anti-inflammatory substance. However, βC has high hydrophobicity property, indicating a low absorption...”
nanostructured lipid carrier (NLC) enhances bioaccessibility of β-carotene
“Lipid-based delivery systems such as nanostructured lipid carriers (NLC) potentially can help to overcome this problem. This research evaluated the bioaccessibility of the nanostructured mixture of pa...”