The Protective Effect of Anethole against Renal Ischemia/Reperfusion: The Role of the TLR2,4/MYD88/NFκB Pathway
Maged E. Mohamed, Mahmoud Kandeel, Hany M. Abd El‐Lateef, Hossam S. El‐Beltagi, Nancy S. Younis
Antioxidants
Abstract
Anethole displayed anti-inflammatory, anti-oxidant, and anti-apoptotic actions against RIR-induced injury. Anethole exhibited renal protective actions, which could be through inhibiting the HMGB1/TLR2, 4/MYD88/NFκB pathway. These results could suggest anethole as a protective agent against RIR.
Concepts
AnetholeChemistryPharmacologyKidneyRenal ischemiaRenal function