The positive effects and underlying mechanisms of <i>Undaria pinnatifida</i> polysaccharides on type 2 diabetes mellitus in rats
Zhao‐Rong Li, Rui‐Bo Jia, Donghui Luo, Lianzhu Lin, Qianwen Zheng, Mouming Zhao
Food & Function
Abstract
The aim of the current work was to investigate the anti-diabetic effects and underlying mechanisms of <i>Undaria pinnatifida</i> polysaccharides (UPP) based on a type 2 diabetes (T2DM) rat model. The starch loading test showed that UPP administration could reduce blood glucose fluctuations caused by eating. Analysis of diabetic symptoms and biochemical profiles showed that UPP intervention markedly decreased fasting blood glucose level, mitigated insulin resistance, improved glucose tolerance, dyslipidemia and liver and kidney damage in diabetic rats. The 16S rRNA analysis demonstrated that UPP intervention could markedly change the intestinal microflora composition, causing increases in <i>Alistipes</i>, <i>Bacteroides</i>, <i>Christensenellaceae</i>_R-7_group, <i>Desulfovibrio</i>, <i>Muribaculaceae</i>_norank, <i>Ruminococcaceae</i>_UCG-013, and <i>Ruminococcaceae</i>_UCG-014, and a decrease in <i>Escherichia-Shigella</i>. Furthermore, RT-qPCR analysis results clarified that UPP administration distinctly activated the IRS/PI3K/AKT signaling pathway, restrained PEPCK, G-6-Pase and Egr-1 genes, and affected the relative expression of HMGCR and LDLR genes. This study demonstrates that UPP could be applied as an adjuvant agent for the management of T2DM.
Extracted Claims
4 claims extracted from this paper into the knowledge graph
UPP administration activated the IRS/PI3K/AKT signaling pathway, restrained PEPCK, G-6-Pase and Egr-1 genes, and affected the relative expression of HMGCR and LDLR genes
“RT-qPCR analysis results clarified that UPP administration distinctly activated the IRS/PI3K/AKT signaling pathway, restrained PEPCK, G-6-Pase and Egr-1 genes, and affected the relative expression of ...”
Undaria pinnatifida polysaccharides (UPP) reduce blood glucose fluctuations caused by eating
“The starch loading test showed that UPP administration could reduce blood glucose fluctuations caused by eating.”
UPP intervention decreased fasting blood glucose level, mitigated insulin resistance, improved glucose tolerance, dyslipidemia and liver and kidney damage in diabetic rats
“Analysis of diabetic symptoms and biochemical profiles showed that UPP intervention markedly decreased fasting blood glucose level, mitigated insulin resistance, improved glucose tolerance, dyslipidem...”