2021peer-reviewed53 citations
Effect of IV High-Dose Vitamin C on Mortality in Patients With Sepsis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials*
Ryota Sato, Daisuke Hasegawa, Narut Prasitlumkum, M. Ueoka, Kazuki Nishida, Kunihiko Takahashi +2 more
Critical Care Medicine
Abstract
In this meta-analysis, the use of IV high-dose vitamin C in patients with sepsis was not associated with lower short-term mortality although it was associated with significantly shorter duration of vasopressor use and greater decline in the Sequential Organ Failure Assessment score at 72-96 hours.
Concepts
MedicineRandomized controlled trialMeta-analysisSepsisInternal medicineRelative riskCochrane LibraryClinical trial