A review on traditional uses, phytochemistry, pharmacology, and clinical research of dietary spice <scp><i>Cuminum cyminum</i></scp> L.
Neetu Singh, Surender Singh Yadav, Sanjiv Kumar, Balasubramaniam Narashiman
Phytotherapy Research
Abstract
Cuminum cyminum L. is a versatile spice belonging to family Apiaceae. Though the plant has pan-tropical distribution but it is indigenous to Egypt, the Mediterranean, and South Asian countries. It exhibits numerous culinary, traditional, and pharmacological attributes. Its traditional uses also validate its immense pharmacological potential. Cuminum cyminum is the hub of numerous bioactives such as alkaloids, flavonoids, terpenoids, and so forth. Cuminaldehyde is the major bioactive, rendered to most of its pharmacological as well as clinical significance. The present study comprised of current knowledge on its taxonomy, nutritional, traditional, phytochemistry, pharmacology (antimicrobial, antioxidant, anti-inflammation, antidiabetic, wound healing, anticancer, etc.), toxicology, and clinical attributes. Besides, the mechanism of action is also well explained. The present study provides a rationale for further bioprospection of this wonder plant. Future studies are needed to fill the research gaps, particularly on relevant phytocompound isolation, their pre-clinical and clinical characterization, evaluation, and structure-activity relationship. Moreover, well-designed and highly appropriate clinical and placebo trials are still needed to demonstrate the trustworthy role of cumin on human health.
Extracted Claims
3 claims extracted from this paper into the knowledge graph
Cuminum cyminum L. is indigenous to Egypt, the Mediterranean, and South Asian countries
“Though the plant has pan-tropical distribution but it is indigenous to Egypt, the Mediterranean, and South Asian countries.”
cuminaldehyde is responsible for pharmacological and clinical significance
“Cuminaldehyde is the major bioactive, rendered to most of its pharmacological as well as clinical significance.”
Cuminum cyminum exhibits antimicrobial, antioxidant, anti-inflammation, antidiabetic, wound healing, anticancer properties
“It exhibits numerous culinary, traditional, and pharmacological attributes. Its traditional uses also validate its immense pharmacological potential. Cuminum cyminum is the hub of numerous bioactives ...”