Effect of dietary supplementation with oat β-glucan for 3 months in subjects with type 2 diabetes: A randomized, double-blind, controlled clinical trial
José Luis Pino, Verónica Mujica, Miguel Arredondo
Journal of Functional Foods
Abstract
There is a growing interest in the use of functional foods. Studies indicate the contribution of β-glucans to glycemic control, but few have evaluated integrally the effect of this soluble dietary fiber on appetite-regulating hormones and microbiota in type-2 diabetes (T2D). We analyzed the effect of enriching a normal diet with oat β-glucan in thirty-seven T2D subjects. For 12 weeks, subjects consumed daily oat β-glucan or microcrystalline cellulose as control (5 g/day). We determined fasting glucose, C-peptide, insulin, HOMA, HbA1c, lipid profile, ghrelin, leptin, GLP-1, PYY, caloric intake, and intestinal microbiota. HbA1c decreased in the β-glucan group. Insulin, C-peptide and HOMA, Lactobacillus spp, and Butyrate-producing bacteria decreased in the β-glucan group (p < 0.05). Leptin (p < 0.05), GLP-1 (p < 0.01) and PYY (p < 0.001) were different between groups. The intake of 5 g/oat β-glucan for 12 weeks can help improve glycemic control, increase the feeling of satiety, and promote changes in the gut microbiota profile.
Extracted Claims
12 claims extracted from this paper into the knowledge graph
oat β-glucan increased feeling of satiety
“The intake of 5 g/oat β-glucan for 12 weeks can help improve glycemic control, increase the feeling of satiety, and promote changes in the gut microbiota profile.”
oat β-glucan decreased HbA1c
“HbA1c decreased in the β-glucan group.”
oat β-glucan increased GLP-1
“Leptin (p < 0.05), GLP-1 (p < 0.01) and PYY (p < 0.001) were different between groups.”