Encapsulation of anthocyanins from bilberries – Effects on bioavailability and intestinal accessibility in humans
Dolores Mueller, Kathrin Jung, Manuel Winter, Dorothee Rogoll, Ralph Melcher, Ulrich Kulozik +2 more
Food Chemistry
Abstract
Anthocyanins are flavonoids that have been suggested to provide beneficial health effects. The biological activity of anthocyanins is influenced by their pharmacokinetic properties, but anthocyanins are associated with limited bioavailability in humans. In the presented study, we investigated how the encapsulation of bilberry extract (BE), a source of anthocyanins, with either whey protein or citrus pectin influences the bioavailability and intestinal accessibility of anthocyanins in humans. We performed an intervention study that analyzed anthocyanins and their degradation products in the urine, plasma, and ileal effluent of healthy volunteers and ileostomists (subjects without an intact colon). We were able to show, that whey protein encapsulation modulated short-term bioavailability and that citrus pectin encapsulation increased intestinal accessibility during passage through the small intestine and modulated the formation of the degradation product phloroglucinol aldehyde (PGAL) in human plasma.
Extracted Claims
4 claims extracted from this paper into the knowledge graph
citrus pectin encapsulation increases intestinal accessibility
“citrus pectin encapsulation increased intestinal accessibility during passage through the small intestine”
citrus pectin encapsulation modulates formation of phloroglucinol aldehyde (PGAL) in human plasma
“citrus pectin encapsulation modulated the formation of the degradation product phloroglucinol aldehyde (PGAL) in human plasma.”
anthocyanins influences bioavailability
“The biological activity of anthocyanins is influenced by their pharmacokinetic properties, but anthocyanins are associated with limited bioavailability in humans.”