<i>In Vitro</i>Antimicrobial Activity and Effect on Biofilm Production of a White Grape Juice (<i>Vitis vinifera</i>) Extract
Angela Filocamo, Giuseppe Bisignano, Giuseppina Mandalari, Michele Navarra
Evidence-based Complementary and Alternative Medicine
Abstract
Background. The aim of the present study was to evaluate the antimicrobial effect of a white grape juice extract (WGJe) against a range of Gram-positive and Gram-negative bacteria, yeasts, and the fungus Aspergillus niger. WGJe was also tested on the production of bacterial biofilms in vitro. Results. WGJe inhibited in vitro most Gram-positive bacteria tested, Staphylococcus aureus ATCC 6538P being the most sensitive strain (MIC values of 3.9 μg/mL). The effect was bactericidal at the concentration of 500 μg/mL. Amongst the Gram-negative bacteria, Escherichia coli was the only susceptible strain (MIC and MBC of 2000 μg/mL). No effect on the growth of Candida sp. and the fungus Aspergillus niger was detected (MIC values > 2000 μg/mL). WGJe inhibited the biofilms formation of E. coli and Pseudomonas aeruginosa with a dose-dependent effect. Conclusions. WGJe exerted both bacteriostatic and bactericidal activity in vitro. The presented results could be used to develop novel strategies for the treatment of skin infections and against potential respiratory pathogens.
Extracted Claims
5 claims extracted from this paper into the knowledge graph
white grape juice extract (WGJe) exerted bactericidal activity
“The effect was bactericidal at the concentration of 500 μg/mL.”
white grape juice extract (WGJe) inhibited biofilm formation
“WGJe inhibited the biofilms formation of E. coli and Pseudomonas aeruginosa with a dose-dependent effect.”
white grape juice extract (WGJe) inhibited Gram-positive bacteria
“WGJe inhibited in vitro most Gram-positive bacteria tested, Staphylococcus aureus ATCC 6538P being the most sensitive strain (MIC values of 3.9 μg/mL).”