Genetic Influences on Oral Fat Perception and Preference
Kathleen Keller
Journal of Food Science
Abstract
Research suggests that dietary fat is perceived not only by texture, but also by taste. However, the receptors for chemosensory response to fat have not been identified. We report on 2 genes,TAS2R38 and CD36, that may play a role in fat perception and preference in humans. TAS2R38 is a taste receptor for bitter thiourea compounds, including 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC). Nontasters of these compounds tend to be poor at discriminating fat in foods, even though they prefer higher fat versions of these foods. CD36, a fatty acid translocase expressed on multiple cell types including taste cells, plays a critical role in fat preferences in animals. In studies conducted in our laboratory with African-American adults, we identified a variant in the CD36 gene, rs1761667, that predicts oral responses to fat. Individuals who have the A/A genotype at this site tend to find Italian salad dressings creamier than those who have other genotypes at this site. In addition, A/A individuals report higher preferences for added fats, oils, and spreads (for example margarine). Assuming these data are confirmed in other populations, screening for CD36 genotype may provide helpful information to food companies for developing fat-modified products.
Extracted Claims
5 claims extracted from this paper into the knowledge graph
TAS2R38 plays a role in fat perception and preference
“TAS2R38 is a taste receptor for bitter thiourea compounds, including 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC). Nontasters of these compounds tend to be poor at discriminating fat in f...”
CD36 variant rs1761667 predicts oral responses to fat
“In studies conducted in our laboratory with African-American adults, we identified a variant in the CD36 gene, rs1761667, that predicts oral responses to fat.”
CD36 plays a critical role in fat preferences in animals
“CD36, a fatty acid translocase expressed on multiple cell types including taste cells, plays a critical role in fat preferences in animals.”