Effects of Cod Liver Oil on Platelets and Coagulation in Familial Hypercholesterolemia (Type IIa)
Jan Brox, Jan E. Killie, Bjarne Østerud, S. Holme, Arne Nordøy
Acta Medica Scandinavica
Abstract
Patients with familial hypercholesterolemia (type IIa) were given 30 ml cod liver oil (CLO) as dietary supplement daily for 6 weeks. The effects on platelets, bleeding time, coagulation and blood and platelet lipids were examined. The major findings were a reduced collagen-induced platelet aggregation and a decrease in thrombin-stimulated thromboxane B2 generation in platelets in vitro. The primary bleeding time was not significantly prolonged. Statistically significant increase in eicosapentaenoic acid/arachidonic acid ratios in the main platelet phospholipids were also observed. These changes did not correlate with any of the changes in platelet behavior observed after CLO intake. The serum total and HDL cholesterol and triglycerides were not altered during the trial.
Extracted Claims
3 claims extracted from this paper into the knowledge graph
cod liver oil decreased thrombin-stimulated thromboxane B2 generation in platelets
“and a decrease in thrombin-stimulated thromboxane B2 generation in platelets in vitro.”
cod liver oil increased eicosapentaenoic acid/arachidonic acid ratios in the main platelet phospholipids
“Statistically significant increase in eicosapentaenoic acid/arachidonic acid ratios in the main platelet phospholipids were also observed.”
cod liver oil reduced collagen-induced platelet aggregation
“The major findings were a reduced collagen-induced platelet aggregation”