Laxatives and the production of autacoids by rat colon
Francesco Capasso, Nicola Mascolo, Giuseppina Autore, Vito Romano
Journal of Pharmacy and Pharmacology
Abstract
The effects of some laxatives were examined on the formation of histamine, 5-hydroxytryptamine (5-HT) and prostaglandin-like material (PG-LM) by rat intestine in-vitro. Castor oil, senna, sulphosuccinate and bisacodyl, but not mannitol or lactulose, in doses that cause laxation, increased the formation of histamine, 5-HT and PG-LM. Indomethacin or hydrocortisone reduced the increase of PG-LM formation. The data support the idea that the laxative effects of these intestinal secretagogues are due to increased intestinal production of PG-LM, histamine and 5-HT.
Extracted Claims
4 claims extracted from this paper into the knowledge graph
indomethacin, hydrocortisone reduce PG-LM formation
“Indomethacin or hydrocortisone reduced the increase of PG-LM formation.”
castor oil, senna, sulphosuccinate, bisacodyl increase histamine formation
“Castor oil, senna, sulphosuccinate and bisacodyl, but not mannitol or lactulose, in doses that cause laxation, increased the formation of histamine, 5-hydroxytryptamine (5-HT) and prostaglandin-like m...”
castor oil, senna, sulphosuccinate, bisacodyl increase 5-hydroxytryptamine (5-HT) formation
“Castor oil, senna, sulphosuccinate and bisacodyl, but not mannitol or lactulose, in doses that cause laxation, increased the formation of histamine, 5-hydroxytryptamine (5-HT) and prostaglandin-like m...”