Blackberry Extract Attenuates Oxidative Stress through Up-regulation of Nrf2-Dependent Antioxidant Enzymes in Carbon Tetrachloride-Treated Rats
Byoung Ok Cho, Hyung Won Ryu, Chang Hyun Jin, Dae Seong Choi, Si Yong Kang, Dong Sub Kim +2 more
Journal of Agricultural and Food Chemistry
Abstract
The aim of this study was to investigate the protective ability of blackberry extract (BE) against oxidative stress in carbon tetrachloride (CCl(4))-treated rats. The results showed that treatment with BE attenuated lipid peroxidation that was increased by CCl(4) and also markedly recovered the activity of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), that were decreased by CCl(4). BE also elevated the protein expression levels of NF-E2-related factor-2 (Nrf2), CuZnSOD, MnSOD, GPx-1/2, and heme oxygenase-1 (HO-1), but not that of catalase. Furthermore, the administration of BE significantly attenuated the levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) that were increased by CCl(4). Therefore, the present study suggests that BE possesses significant protective effects against in vivo oxidative stress.
Extracted Claims
4 claims extracted from this paper into the knowledge graph
blackberry extract (BE) recovered antioxidant enzyme activity
“markedly recovered the activity of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), that were decreased by CCl(4)”
blackberry extract (BE) attenuated serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels
“the administration of BE significantly attenuated the levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) that were increased by CCl(4)”
blackberry extract (BE) attenuates lipid peroxidation
“treatment with BE attenuated lipid peroxidation that was increased by CCl(4)”