The <i>n</i> -Butanol Fraction and Rutin from Tartary Buckwheat Improve Cognition and Memory in an <i>In Vivo</i> Model of Amyloid- <i>β</i> -Induced Alzheimer's Disease
Ji Yeon Choi, Jeong Min Lee, Dong Gu Lee, Sunghun Cho, Young-Ho Yoon, Eun Ju Cho +1 more
Journal of Medicinal Food
Abstract
This study examined the beneficial effects of the n-butanol fraction and rutin extracted from tartary buckwheat (TB) on learning and memory deficits in a mouse model of amyloid β (Aβ)-induced Alzheimer's disease (AD). Learning and memory were assessed using the T-maze, object recognition, and Morris water maze tests. Animals administered Aβ showed impaired cognition and memory, which were alleviated by oral administration of an n-butanol fraction and rutin extracted from TB. Similarly, Aβ-induced increases in nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys were attenuated by treatment with n-butanol fraction and rutin from TB in addition to antioxidant effects observed in control (nonAβ-treated) animals. The results of the present study suggest that the n-butanol fraction and rutin extracted from TB are protective against and have possible therapeutic applications for the treatment of AD.
Extracted Claims
2 claims extracted from this paper into the knowledge graph
n-butanol fraction and rutin from tartary buckwheat improves cognition and memory
“Learning and memory were assessed using the T-maze, object recognition, and Morris water maze tests. Animals administered Aβ showed impaired cognition and memory, which were alleviated by oral adminis...”
n-butanol fraction and rutin from tartary buckwheat attenuates nitric oxide formation and lipid peroxidation
“Aβ-induced increases in nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys were attenuated by treatment with n-butanol fraction and rutin from TB in addition to antioxidant...”