VK

“inhibition of the vitamin K-cycle by vitamin K antagonists (VKA) results in elevated uncarboxylated MGP (ucMGP) and subsequently in extensive arterial calcification”

vitamin K antagonists (VKA) → result in → extensive arterial calcification

“The carboxylation state of osteocalcin and PIVKA-II were the most sensitive indices of changes in vitamin K1 status.”

carboxylation state of osteocalcin and PIVKA-II → were the most sensitive indices of → changes in vitamin K1 status

“we have developed a series of potent VK analogues with favorable drug characteristics that provide full protection at nanomolar concentrations in a well-defined model of neuronal oxidative stress”

VK analogues → provide → full protection

“We found that when VK was combined with sorafenib, the concentration of sorafenib required for growth inhibition was substantially reduced.”

vitamin K (VK) → reduces → concentration of sorafenib required for growth inhibition

“Conversely, VK enhanced sorafenib effects in several HCC cell lines on growth inhibition.”

VK → enhances → sorafenib effects on growth inhibition